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Can I read Involvement of rRNA synthesis in the enhanced survival and recovery of protein synthesis seen in thermotolerance on EtoBox?
Involvement of rRNA synthesis in the enhanced survival and recovery of protein synthesis seen in thermotolerance by Adrian R. Black; John R. Subjeck is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Involvement of rRNA synthesis in the enhanced survival and recovery of protein synthesis seen in thermotolerance about?
Although acquired thermotolerance has been linked to the induction of heat shock proteins, the molecular mechanismh) by which cells become resistant to heat is unknown. The present study shows a strong correlation between the survival of cells following heat shock and the rate of recovery of protein, total KNA, and rRNA synthesis. Increasing exposure of CHO cclls to 45°C was found to decrease survival and cause a lengthening delay in these synthetic processes. The same reciprocal correlation was seen in thermotolerant cells. As thermotolcrance develops, more cells survive a heat challenge and the delay in synthesis decreases. These d a h argue that enhanced recovery of protein and KNA synthesis is one factor which plays a key role in thermotolerance. The involvement of rRNA synthesis was further investigated by using actinomycin D at 0.1 pg m l -I , a concentration at which rKNA synthesis is selectively inhibited. When the drug was present during the recovery from a challenge heat treatment, the survival of thermotolcrant cells was -3-fold lower than expected from the mild toxicity of the drug. As this could not be accounted for by an interaction of the drug with the response of ce
Who reads Involvement of rRNA synthesis in the enhanced survival and recovery of protein synthesis seen in thermotolerance?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Adrian R. Black; John R. Subjeck
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1989
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)