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Early intrahepatic antigen-specific retention of naïve CD8^+^T cells is predominantly ICAM-1/LFA-1 dependent in mice by Patrick Bertolino; Arnhild Schrage; David G. Bowen; Katja Klugewitz; Saeed Ghani; Katharina Eulenburg; Lauren Holz; Nancy Hogg; Geoffrey W. McCaughan; Alf Hamann is a Medicine article available to read on EtoBox.
What is Early intrahepatic antigen-specific retention of naïve CD8^+^T cells is predominantly ICAM-1/LFA-1 dependent in mice about?
We have previously shown that naïve CD8+ T cells recognizing their cognate antigen within the liver are retained and undergo activation in situ, independent from lymphoid tissues. Intrahepatic primary T cell activation results in apoptosis and may play a crucial role in the ability of the liver to induce tolerance. Although adhesion molecules required for intrahepatic retention of T cells that have undergone previous extra-hepatic activation have been characterized, adhesive interactions involved in selective antigen-dependent intrahepatic retention of naïve CD8+ T cells have not been investigated. By adoptively transferring radiolabeled T cell receptor (TCR)-transgenic CD8+ T cells into recipient animals ubiquitously expressing the relevant antigen, we show that 40% to 60 % of donor antigen-specific naïve CD8+ T cells were retained in the liver within 1 hour after transfer, despite ubiquitous expression of the antigen. Intravital microscopy showed that most donor naïve T cells slowed down and were irreversibly retained intrahepatically within the first few minutes after adoptive transfer, strongly suggesting that they were directly activated by liver cells in situ. This process wa
Who reads Early intrahepatic antigen-specific retention of naïve CD8^+^T cells is predominantly ICAM-1/LFA-1 dependent in mice?
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- Author
- Patrick Bertolino; Arnhild Schrage; David G. Bowen; Katja Klugewitz; Saeed Ghani; Katharina Eulenburg; Lauren Holz; Nancy Hogg; Geoffrey W. McCaughan; Alf Hamann
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)