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Oral Administration of Diphenyl Diselenide Potentiates Hepatotoxicity Induced by Carbon Tetrachloride in Rats by Cristina W. Nogueira; Lysandro Pinto Borges; Ana Cristina Guerra Souza is a Environmental Science article available to read on EtoBox.

What is Oral Administration of Diphenyl Diselenide Potentiates Hepatotoxicity Induced by Carbon Tetrachloride in Rats about?

Carbon tetrachloride (CCl 4 ) is a model for studying free radical-induced liver injury and screening hepato-protective drugs. Numerous studies have reported the involvement of oxidative stress in CCl 4 -induced liver damage and the hepato-protective effects mediated by different antioxidants. The present study examined the effects of diphenyl diselenide, (PhSe) 2 , on hepatotoxicity induced by CCl 4 in rats. To this end, male Wistar rats received (PhSe) 2 by oral route at the dosage of 31.2 mg/kg for one or two days. After the second day of treatment, rats received CCl 4 orally in a single dose. The liver and kidney were utilized for determination of histopathology, biochemical [aspartate (ALT) and alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, ascorbic acid, nonprotein thiols (NPSH) and aminolevulinate dehydratase (d-ALA-D) activity]. Repeated administration of (PhSe) 2 caused a marked potentiation of hepatotoxicity induced by CCl 4 exposure, as manifested by an increase in biochemical parameters (AST, ALT, ALP, G

Who reads Oral Administration of Diphenyl Diselenide Potentiates Hepatotoxicity Induced by Carbon Tetrachloride in Rats?

Author

Cristina W. Nogueira; Lysandro Pinto Borges; Ana Cristina Guerra Souza

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

2008

Language

EN

Field

Environmental Science (Physical Sciences)