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Can I read Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering on EtoBox?
Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering by Marie Kubota; Iori Okabe; Shin-ichi Nakakita; Ayako Ueo; Yuta Shirogane; Yusuke Yanagi; Takao Hashiguchi is a Medicine article available to read on EtoBox.
What is Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering about?
Despite the use of effective live vaccines, mumps outbreaks still occur worldwide. Mumps virus (MuV) infection typically causes flu-like symptoms and parotid gland swelling but sometimes leads to orchitis, oophoritis, and neurological complications, such as meningitis, encephalitis, and deafness. MuV enters the host cell through membrane fusion mediated by two viral proteins, a receptor-binding attachment protein, and a fusion protein, but its detailed mechanism is not fully understood. In this study, we show that the tetramer (dimer of dimers) formation of the MuV attachment protein head domain is supported by an anion located at the interface between two dimers and that the dimer-dimer interaction plays an important role in triggering the activation of the fusion protein and causing membrane fusion. These results not only further our understanding of MuV entry but provide useful information about a possible target for antiviral drugs.
Who reads Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marie Kubota; Iori Okabe; Shin-ichi Nakakita; Ayako Ueo; Yuta Shirogane; Yusuke Yanagi; Takao Hashiguchi
- Publisher
- American Society for Microbiology (ISSN 0022-538X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)