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The Influence of a Dominating Centre on a Quantitative Systematic Review of Granisetron for Preventing Postoperative Nausea and Vomiting by P. Kranke; C. C. Apfel; L. H. Eberhart; M. Georgieff; N. Roewer is a Medicine article available to read on EtoBox.

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**Background:** We performed a meta‐analysis on granisetron in the prevention of postoperative nausea and vomiting (PONV) and further investigated whether total results and the dose–response characteristics may be significantly affected by a single centre. **Methods:** Systematically searched randomised controlled trials (RCT) using granisetron for the prevention of PONV after general anaesthesia were included in the analysis. The pooled relative risks (RR) and numbers needed to treat (NNT) with their corresponding 95%‐confidence intervals (CI) were calculated. For all centres, one dominating centre and other centres pooled, comparisons were performed according to all doses, low dose (≤20 μg/kg) and high dose (>20 μg/kg) granisetron. **Results:** A total of 27 RCT with 2938 patients were included in the analysis. RR (CI) to suffer from PONV with granisetron when all comparisons were considered was 0.46 (0.39–0.54), 0.7 (0.6–0.81) and 0.34 (0.28–0.41) for all doses, low and high dose, respectively. RR of the dominating centre (1867 patients) were significantly better compared to the remaining centres (1071 patients), with 0.41 (0.34–0.49) and 0.60 (0.49–0.73), respectively. In the d

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Author

P. Kranke; C. C. Apfel; L. H. Eberhart; M. Georgieff; N. Roewer

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-5172)

Published

2001

Language

EN

Field

Medicine (Health Sciences)