Can I read The Therapeutic Potential of Cell Cycle Targeting in Multiple Myeloma on EtoBox?

The Therapeutic Potential of Cell Cycle Targeting in Multiple Myeloma by Anke Maes; Eline Menu; Kim De Veirman; Ken Maes; Karin Vanderkerken; Elke De Bruyne is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Therapeutic Potential of Cell Cycle Targeting in Multiple Myeloma about?

Proper cell cycle progression through the interphase and mitosis is regulated by coordinated activation of important cell cycle proteins (including cyclin-dependent kinases and mitotic kinases) and several checkpoint pathways. Aberrant activity of these cell cycle proteins and checkpoint pathways results in deregulation of cell cycle progression, which is one of the key hallmarks of cancer. Consequently, intensive research on targeting these cell cycle regulatory proteins identified several candidate small molecule inhibitors that are able to induce cell cycle arrest and even apoptosis in cancer cells. Importantly, several of these cell cycle regulatory proteins have also been proposed as therapeutic targets in the plasma cell malignancy multiple myeloma (MM). Despite the enormous progress in the treatment of MM the past 5 years, MM still remains most often incurable due to the development of drug resistance. Deregulated expression of the cyclins D is observed in virtually all myeloma patients, emphasizing the potential therapeutic interest of cyclin-dependent kinase inhibitors in MM. Furthermore, other targets have also been identified in MM, such as microtubules, kinesin motor pr

Who reads The Therapeutic Potential of Cell Cycle Targeting in Multiple Myeloma?

Author

Anke Maes; Eline Menu; Kim De Veirman; Ken Maes; Karin Vanderkerken; Elke De Bruyne

Publisher

Impact Journals, LLC

Published

2017

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)