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Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: Comparison with early DNA damage by Menno van Lookeren Campagne; Ramanjit Gill is a Neuroscience article available to read on EtoBox.

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Oxidative stress affecting DNA integrity may be an important mediator of cell death induced by cerebral ischemia followed by reperfusion. Genes involved in the DNA repair processes may play an important role in cell viability. We studied the spatial expression of the DNA damage inducible gene p53 and its transcriptional targets p21 WAF1/CIP1 , cyclin G1, and Bax and compared their expression with markers of early DNA damage following 10 min of transient forebrain ischemia in rats. Cyclin G1 and p21 WAF1/CIP1 mRNA levels increased significantly between 2.5 and 4-fold in neurons of the hippocampus, cortex, and striatum during the first 24 hr after reperfusion and decreased at 48 hr of reperfusion. Significant increases in the protein levels of Cyclin G1 and p21 WAF1/CIP1 were only seen in the striatum at 48 hr of reperfusion. The mRNA levels of the p21 family members p27 KIP1 or p57 KIP2 demonstrated no significant changes. p53, bax␣, and bcl-xl mRNA levels increased in all areas of the hippocampus by 12 to 24 hr and decreased over the next 2 days of reperfusion. bax␣ mRNA was specifically induced in neurons of the outer cortical layers at 12 and 24 hr after reperfusion, and protein

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Author

Menno van Lookeren Campagne; Ramanjit Gill

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)