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Diagnostic accuracy of the PLASMIC score in patients with suspected thrombotic thrombocytopenic purpura: A systematic review and meta‐analysis by Koosha Paydary; Emma Banwell; Jiayi Tong; Yong Chen; Adam Cuker is a Medicine article available to read on EtoBox.

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## Background: The plasmic score was developed to identify patients with thrombotic microangiopathy who are most likely to have immune thrombotic thrombocytopenic purpura (ttp) and benefit from therapeutic plasma exchange (tpe). plasmic scores of 0-4, 5, and 6-7 are said to correspond to low, intermediate, and high probability of ttp, respectively. ## Study design and methods: We conducted a systematic review and meta-analysis on the diagnostic accuracy of the plasmic score in adults with suspected ttp. we evaluated the sensitivity, specificity, positive predictive value, and negative predictive value (npv) of plasmic score thresholds of ≥5 and ≥6. study quality was appraised using the quadas-2 tool. ## Results: We identified 13 eligible studies, which collectively enrolled 970 patients. the median prevalence of ttp among eligible studies was 35%. the sensitivity and specificity of a plasmic score ≥5 was 0.99 (95% confidence interval [ci], 0.91-1.00) and 0.57 (95% ci, 0.41-0.72), respectively. at a prevalence of 35%, the npv of a plasmic score ≥5 was 0.99 (95% ci, 0.92-1.00). a plasmic score ≥6 was associated with a sensitivity and specificity of 0.85 (95% ci, 0.67-0.94) and 0.89 (

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Author

Koosha Paydary; Emma Banwell; Jiayi Tong; Yong Chen; Adam Cuker

Published

2020

Language

EN

Field

Medicine (Health Sciences)