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Host genetic control of HPV 16 titer in carcinoma in situ of the cervix uteri by Anna H. Beskow; Ulf B. Gyllensten is a Medicine article available to read on EtoBox.

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## Abstract Cervical cancer is strongly associated with infection by oncogenic forms of human papillomavirus (HPV). Although most women are able to clear an HPV infection, some develop persistent infections that may lead to cancer. The determinants of persistent infection are largely unknown. We have previously shown that women developing carcinoma __in situ__ of the cervix uteri have higher titers of HPV 16 long before development of cervical neoplasia, indicating that the immune response to HPV is important in determining the outcome of an infection. The HLA class II alleles DRB1\*1501 and DQB1\*0602 have previously been associated with an increased risk of HPV infection, and carriers of these alleles also tend to have more long‐term infections. Together these results indicate that certain HLA alleles may affect the ability to control the HPV copy number. To evaluate this possibility, we studied the HLA class II DRB1\*1501‐DQB1\*0602 haplotype, as well as the alleles individually, and the HPV 16 titer in 928 women from a retrospective case‐control study (441 cases and 487 controls). Carriers of the haplotype DRB1\*1501‐DQB1\*0602 allele have a significantly higher HPV 16 titer co

Who reads Host genetic control of HPV 16 titer in carcinoma in situ of the cervix uteri?

Author

Anna H. Beskow; Ulf B. Gyllensten

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2002

Language

EN

Field

Medicine (Health Sciences)