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Can I read Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing on EtoBox?
Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing by Mariagrazia Pizza; Vincenzo Scarlato; Vega Masignani; Marzia Monica Giuliani; Beatrice Aricò; Maurizio Comanducci; Gary T. Jennings; Lucia Baldi; Erika Bartolini; Barbara Capecchi; Cesira L. Galeotti; Enrico Luzzi; Roberto Manetti; Elisa Marchetti; Marirosa Mora; Sandra Nuti; Giulio Ratti; Laura Santini; Silvana Savino; Maria Scarselli; Elisa Storni; Peijun Zuo; Michael Broeker; Erika Hundt; Bernard Knapp; Eric Blair; Tanya Mason; Hervé Tettelin; Derek W. Hood; Alex C. Jeffries; Nigel J. Saunders; Dan M. Granoff; J. Craig Venter; E. Richard Moxon; Guido Grandi; Rino Rappuoli is a Medicine article available to read on EtoBox.
What is Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing about?
__Neisseria meningitidis__is a major cause of bacterial septicemia and meningitis__.__Sequence variation of surface-exposed proteins and cross-reactivity of the serogroup B capsular polysaccharide with human tissues have hampered efforts to develop a successful vaccine. To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. A total of 350 candidate antigens were expressed in__Escherichia coli__, purified, and used to immunize mice. The sera allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.
Who reads Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mariagrazia Pizza; Vincenzo Scarlato; Vega Masignani; Marzia Monica Giuliani; Beatrice Aricò; Maurizio Comanducci; Gary T. Jennings; Lucia Baldi; Erika Bartolini; Barbara Capecchi; Cesira L. Galeotti; Enrico Luzzi; Roberto Manetti; Elisa Marchetti; Marirosa Mora; Sandra Nuti; Giulio Ratti; Laura Santini; Silvana Savino; Maria Scarselli; Elisa Storni; Peijun Zuo; Michael Broeker; Erika Hundt; Bernard Knapp; Eric Blair; Tanya Mason; Hervé Tettelin; Derek W. Hood; Alex C. Jeffries; Nigel J. Saunders; Dan M. Granoff; J. Craig Venter; E. Richard Moxon; Guido Grandi; Rino Rappuoli
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Social Sciences)