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Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder by Hiroaki Shiina; Mikio Igawa; Haruhiko Nagami; Hiroshi Yagi; Shinji Urakami; Tatsuaki Yoneda; Hiroki Shirakawa; Tomoyuki Ishibe; Masahiro Kawanishi is a Medicine article available to read on EtoBox.
What is Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder about?
## Background: Transitional cell carcinoma (tcc) of the bladder displays an unpredictable biologic behavior and the morphologic methods of grading tumor malignancy are often insufficient to predict the clinical outcome of patients with tcc of the bladder. thus, the new indicator should reliably reflect prognosis. in this study, the authors determined the prognostic significance of proliferating cell nuclear antigen (pcna), p53 protein, and nm23 protein, as well as nuclear dna content in specimens with tcc of the bladder. ## Methods: Paraffin embedded materials taken from 77 patients with nonmetastatic untreated tcc of the bladder (classified as pta-3b, no, mo) treated with total cystectomy were employed in this study. pcna expression, p53 protein and nm23 protein immunoreactivities, and the parameters for nuclear dna content such as 2c deviation index (2cdi) and 5c exceeding rate (5cer) were evaluated using a computer-assisted image analyzer, and the results were compared with histologic findings and clinical outcome. ## Results: Pcna expression positively correlated with p53 protein and nm23 protein immunoreactivities, 2cdi value, and 5cer. in addition, histologic grade positively
Who reads Immunohistochemical analysis of proliferating cell nuclear antigen, p53 protein and nm23 protein, and nuclear DNA content in transitional cell carcinoma of the bladder?
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- Author
- Hiroaki Shiina; Mikio Igawa; Haruhiko Nagami; Hiroshi Yagi; Shinji Urakami; Tatsuaki Yoneda; Hiroki Shirakawa; Tomoyuki Ishibe; Masahiro Kawanishi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)