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Hydroxyl Radical Formation Is Greater in Striatal Core Than in Penumbra in a Rat Model of Ischemic Stroke by Shimin Liu; Miao Liu; Steven Peterson; Minoru Miyake; Val Vallyathan; Ke Jian Liu is a Neuroscience article available to read on EtoBox.
What is Hydroxyl Radical Formation Is Greater in Striatal Core Than in Penumbra in a Rat Model of Ischemic Stroke about?
## Abstract Although hydroxyl radical (^•^OH) formation has been implicated in the pathophysiological changes of ischemic stroke, ^•^OH production in the core and penumbra regions is not clear. It is extremely important to distinguish penumbra from ischemic core in focal cerebral ischemia studies, because the penumbra contains viable tissue, which can be salvaged by appropriate treatment. This study evaluated ^•^OH production in both core and penumbra regions of ischemic striatum during ischemia and reperfusion. Microdialysis probes were placed in striatal tissue of rats subjected to the middle cerebral artery occlusion model of ischemic stroke. The ^•^OH‐trapping agent 4‐hydroxybenzoic acid (4‐HBA) was administered by both i.v. and probe infusion. Dialysate levels of the 4‐HBA oxidation products, 3,4‐dihydroxybenzoic acid (3,4‐DHBA), were determined by HPLC‐ECD. After microdialysis probe delivery of 4‐HBA, ^•^OH production was significantly increased in the striatal core during both ischemia and reperfusion. Penumbra ^•^OH production increased only during reperfusion. Alterations of 3,4‐DHBA concentration in dialysate following i.v. 4‐HBA administration were likely related to alte
Who reads Hydroxyl Radical Formation Is Greater in Striatal Core Than in Penumbra in a Rat Model of Ischemic Stroke?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Shimin Liu; Miao Liu; Steven Peterson; Minoru Miyake; Val Vallyathan; Ke Jian Liu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)