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Stromal Biology of Pancreatic Cancer by Gerald C. Chu; Alec C. Kimmelman; Aram F. Hezel; Ronald A. DePinho is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Stromal Biology of Pancreatic Cancer about?

## Abstract The genetic paradigm of cancer, focused largely on sequential molecular aberrations and associated biological impact in the neoplastic cell compartment of malignant tumors, has dominated our view of cancer pathogenesis. For the most part, this conceptualization has overlooked the dynamic and complex contributions of the surrounding microenvironment comprised of non‐tumor cells (stroma) that may resist, react to, and/or foster tumor development. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease in which a prominent tumor stroma compartment is a defining characteristic. Indeed, the bulk of PDAC tumor volume consists of non‐neoplastic fibroblastic, vascular, and inflammatory cells surrounded by immense quantities of extracellular matrix, far exceeding that found in most other tumor types. Remarkably, little is known about the composition and physiology of the PDAC tumor microenvironment, in particular, the role of stroma in tumor initiation and progression. This review attempts to define key challenges, opportunities and state‐of‐knowledge relating to the PDAC microenvironment research with an emphasis on how inflammatory processes and key cancer pathways

Who reads Stromal Biology of Pancreatic Cancer?

Author

Gerald C. Chu; Alec C. Kimmelman; Aram F. Hezel; Ronald A. DePinho

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)