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Synovial C-Reactive Protein is a Useful Adjunct for Diagnosis of Periprosthetic Joint Infection by Colin M. Baker; Graham S. Goh; Saad Tarabichi; Noam Shohat; Javad Parvizi is a Medicine article available to read on EtoBox.

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## Background: The diagnostic utility of synovial c-reactive protein (crp) has been debated for a while. existing studies are limited by small sample sizes and using outdated criteria for periprosthetic joint infection (pji). furthermore, the relationship between synovial and serum crp has rarely been investigated in the setting of pji. this study aimed to evaluate the diagnostic utility of synovial crp and to assess its relationship with serum crp and other common biomarkers. ## Methods: We reviewed 621 patients who underwent evaluation for pji prior to revision arthroplasty from 2014 to 2021. biomarkers, including serum crp and erythrocyte sedimentation rate, synovial crp, polymorphonuclear leukocyte percentage, white blood cell count, and alpha-defensin, were evaluated using the 2018 international consensus meeting criteria. ## Results: In total, 194 patients had a pji; 394 were considered aseptic failures and 33 were inconclusive. synovial crp showed an area under the curve (auc) of 0.951 (95% ci, 0.932-0.970) with 74.2% sensitivity and 98.0% specificity, whereas, serum crp had an auc of 0.926 (95% ci, 0.903-0.949) with 83.5% sensitivity and 88.3% specificity. there was a good

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Author

Colin M. Baker; Graham S. Goh; Saad Tarabichi; Noam Shohat; Javad Parvizi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)