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Neonates with Acute Liver Failure Have Higher Overall Mortality but Similar Posttransplant Outcomes as Older Infants by Swati Antala; Bridget Whitehead; Justin Godown; Matt Hall; Anna Banc‐Husu; Estella M. Alonso; Sarah A. Taylor is a Medicine article available to read on EtoBox.
What is Neonates with Acute Liver Failure Have Higher Overall Mortality but Similar Posttransplant Outcomes as Older Infants about?
Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases. Patients with International Classification of Diseases, Ninth Revision/International Classification of Diseases, Tenth Revision codes for liver failure (2004–2018) from linked Pediatric Health Information System and Scientific Registry of Transplant Recipients databases were assigned to two groups: neonates aged ≤30 days or older infants aged 31–120 days at admission. Billing data were used to assign diagnoses and assess patient comorbidities (sepsis, extracorporeal membrane oxygenation, total parenteral nutrition, intensive care unit, and cardiac/renal/respiratory failure). Statistical analysis included Kaplan–Meier survival curve analysis and univariate and multivariate analyses with the Cox proportional hazards model. We identified 1807 neonates and 890 older infants. Neonates had significantly lower survival to 90 days (__p__ = 0.04) and a lower rate of liver transplantation (2.0% vs. 6.4%; __p__ < 0.001). Common risk factors asso
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- Author
- Swati Antala; Bridget Whitehead; Justin Godown; Matt Hall; Anna Banc‐Husu; Estella M. Alonso; Sarah A. Taylor
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)