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Can I read Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish on EtoBox?
Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish by Wandong Bao; Andrey D. Volgin; Erik T. Alpyshov; Ashton J. Friend; Tatyana V. Strekalova; Murilo S. de Abreu; Christopher Collins; Tamara G. Amstislavskaya; Konstantin A. Demin; Allan V. Kalueff is a Neuroscience article available to read on EtoBox.
What is Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish about?
Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and mechanisms of action are not fully understood. Experimental (animal) models are critical for improving our understanding of opioid effects in vivo. As zebrafish (Danio rerio) are increasingly utilized as a powerful model organism in neuroscience research, mounting evidence suggests these fish as a useful tool to study opioid neurobiology. Here, we discuss the zebrafish opioid system with specific focus on opioid gene expression, existing genetic models, as well as its pharmacological and developmental regulation. As many human brain diseases involve pain and aberrant reward, we also summarize zebrafish models relevant to opioid regulation of pain and addiction, including evidence of functional interplay between the opioid system and central dopaminergic and other neurotransmitter mechanisms. Additionally, we critically evaluate the limitations of zebrafish models for translational opioid research and emphasize their developing utility for improving our understanding of evolutionarily conserved mechanisms of pain-related, addictive, affective and other behaviors, as well as for fostering opioid
Who reads Opioid Neurobiology, Neurogenetics and Neuropharmacology in Zebrafish?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Wandong Bao; Andrey D. Volgin; Erik T. Alpyshov; Ashton J. Friend; Tatyana V. Strekalova; Murilo S. de Abreu; Christopher Collins; Tamara G. Amstislavskaya; Konstantin A. Demin; Allan V. Kalueff
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0306-4522)
- Published
- 2019
- Language
- EN
- Field
- Neuroscience (Life Sciences)