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α-Internexin Is the Only Neuronal Intermediate Filament Expressed in Developing Cerebellar Granule Neurons by C.-L. Chien; C.A. Mason; R.K.H. Liem is a Neuroscience article available to read on EtoBox.

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We have used immunocytochemistry and in situ hybridization to examine the distribution of neuronal intermediate filament proteins and their mRNAs in the developing mouse cerebellum. First, we demonstrate that a-internexin is abundantly expressed in the developing cerebellum and is the only neuronal intermediate filament protein expressed in developing, including migrating, granule neurons. Second, in granule neuron reaggregates in vitro, a-internexin is the only neuronal intermediate filament protein highly expressed in the processes of the cultured granule neurons. This in vitro observation is consistent with results from immunocytochemistry and in situ hybridization studies of developing granule neu-rons in vivo, which suggest that a-internexin is the major neuronal intermediate filament protein in developing granule neurons. Finally, the neurofilament triplet proteins are expressed later, and coexist with a-internexin in other cells, including Purkinje cells and interneurons in the mature mouse cerebellum. These changes in neuronal intermediate filament composition may regulate neuronal maturation and axonal stability in cerebellar development. Furthermore, a-internexin may play

Who reads α-Internexin Is the Only Neuronal Intermediate Filament Expressed in Developing Cerebellar Granule Neurons?

Author

C.-L. Chien; C.A. Mason; R.K.H. Liem

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)