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Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation by Chengya Liang; Megan E. Oest; Jeryl C. Jones; M. Renee Prater is a Medicine article available to read on EtoBox.

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## Abstract **BACKGROUND:** Our present work joins growing evidence that gestational environment (maternal nutrition, health, and chemical exposures) strongly influences prenatal development (www.thebarkertheory.org). The present study suggests that maternal consumption of a diet high in saturated fats (HFD), which approximates the macronutrient content of fast food, impairs perinatal skeletal development. **METHODS:** In this study, administration of HFD (32% saturated fat) for one month prior to conception and throughout gestation in C57BL/6J mice was associated with a marked reduction in late‐gestation fetal skeletal developmental delay that included shorter long bone lengths, decreased average bone mineral density (ABMD; 20%), lower total bone volume (TBV; 45%), and shorter crown‐to‐rump length (C‐R; 12%), as compared to controls. **RESULTS:** A putative mechanism linking prenatal HFD to dysregulated fetal osteogenesis is HFD‐induced oxidative stress (OS), which has been shown in our laboratory to cause placental labyrinthine vascular damage and impaired fetal signaling pathways associated with osteogenesis (Liang et al., unpublished data). **CONCLUSIONS:** The theory of HFD‐as

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Author

Chengya Liang; Megan E. Oest; Jeryl C. Jones; M. Renee Prater

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-9733)

Published

2009

Language

EN

Field

Medicine (Health Sciences)