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Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus by Astrid Zwerdling; M. Victoria Delpino; Paula Barrionuevo; Juliana Cassataro; Karina A. Pasquevich; Clara García Samartino; Carlos A. Fossati; Guillermo H. Giambartolomei is a Medicine article available to read on EtoBox.
What is Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus about?
Infection with Brucella abortus induces a pro-inflammatory response that drives T cell responses toward a Th1 profile. The mechanism by which this bacterium triggers this response is unknown. Dendritic cells (DC) are crucial mediators at the host-pathogen interface and are potent Th1-inducing antigen-presenting cells. Thus, we examined the mechanism whereby B. abortus stimulate human DC maturation. B. abortusinfected DC increased the expression of CD86, CD80, CCR7, CD83, MHCII, MHCI and CD40 and induced the production of TNF-a, IL-6, IL-10 and IL-12. Both phenomena were not dependent on bacterial viability since they were also induced by heat-killed B. abortus (HKBA). B. abortus LPS was unable to induce markers up-regulation or cytokine production. We next investigated the capacity of the outer membrane protein 19 (Omp19) as a B. abortus lipoprotein model to induce DC maturation. Lipidated Omp19 (L-Omp19), but not its unlipidated form, increased the expression of cell surface markers and the secretion of cytokines. L-Omp19-matured DC also have decreased endocytic activity and displayed enhanced T cell stimulatory activity in a MLR. Pre-incubation of DC with anti-TLR2 mAb blocked L-
Who reads Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus?
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- Author
- Astrid Zwerdling; M. Victoria Delpino; Paula Barrionuevo; Juliana Cassataro; Karina A. Pasquevich; Clara García Samartino; Carlos A. Fossati; Guillermo H. Giambartolomei
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Life Sciences)