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Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19‐norsteroids responsible for 19‐norandrosterone and 19‐noretiocholanolone excretion in human urine by Katia De Wasch; Bruno Le Bizec; Hubert De Brabander; François André; Sandra Impens is a Chemistry article available to read on EtoBox.

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## Abstract In previous work (Le Bizec __et al__., __Rapid Commun. Mass Spectrom__. 2000; 14: 1058), it was demonstrated that a boar meal intake could lead to possible false accusations of abuse of 17β‐nortestosterone in antidoping control. The aim of the present study was to identify and quantify endogenous 19‐norsteroids in boar edible tissue at concentrations that can alter the steroid urinary profile in humans, and lead to excretion of 19‐norandrosterone (19‐NA) and 19‐noretiocholanolone (19‐NE). The samples were analysed in two laboratories. The methodologies used for extraction and detection (GC/MS(EI) and LC/MS/MS(APCI+)) are compared and discussed. 19‐Norandrostenedione (NAED), 17β‐ and 17α‐nortestosterone (bNT, aNT), and 17β‐ and 17α‐testosterone (bT, aT) were quantified. The largest concentrations of NAED and bNT were observed in testicles (83 and 172 μg/kg), liver (17 and 63 μg/kg) and kidney (45 and 38 μg/kg). A correlation between the bNT and NAED content of a typical meal prepared with boar parts and the excreted concentrations of 19‐NA and 19‐NE in human urine was demonstrated. Copyright © 2001 John Wiley & Sons, Ltd.

Who reads Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19‐norsteroids responsible for 19‐norandrosterone and 19‐noretiocholanolone excretion in human urine?

Author

Katia De Wasch; Bruno Le Bizec; Hubert De Brabander; François André; Sandra Impens

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)

Published

2001

Language

EN

Field

Chemistry (Physical Sciences)