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Can I read 4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists on EtoBox?
4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists by Robert I. Higuchi; James P. Edwards; Thomas R. Caferro; Josef D. Ringgenberg; James W. Kong; Lawrence G. Hamann; Kristen L. Arienti; Keith B. Marschke; Robert L. Davis; Luc J. Farmer; Todd K. Jones is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is 4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists about?
A series of human androgen receptor (hAR) agonists based on 4-alkyl-; 4,4-dialkyl-; and 3,4dialkyl-l,2,3,4-tetrahydro-8-pyridono[5,6-g]quinoline was synthesized and evaluated in competitive receptor binding assays and an androgen receptor cotransfection assay in a mammalian cell background. A number of compounds in this series demonstrated activity equal to or better than dihydrotestosterone in both assays and represent a novel class of compounds for use in androgen replacement therapy.
Who reads 4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Robert I. Higuchi; James P. Edwards; Thomas R. Caferro; Josef D. Ringgenberg; James W. Kong; Lawrence G. Hamann; Kristen L. Arienti; Keith B. Marschke; Robert L. Davis; Luc J. Farmer; Todd K. Jones
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)