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What is HDAC Inhibition for Diabetes Treatment about?

This document reviews the potential of histone deacetylase (HDAC) inhibitors as a novel treatment for diabetes mellitus. Both type 1 and type 2 diabetes have an inflammatory pathogenesis involving interleukin-1β, which damages insulin-producing beta cells. There is evidence that HDACs are genetically associated with diabetes. HDAC inhibitors promote beta cell development, proliferation and function, and may positively affect late diabetic complications. The document proposes preclinical and clinical trials

Author

greatmaleks

Language

EN