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Atypical Mitotic Figures and the Mitotic Index in Cervical Intraepithelial Neoplasia by A. M. Van Leeuwen; P. M. Burger; W. J. L. M. Pieters; H. Hollema is a Medicine article available to read on EtoBox.

What is Atypical Mitotic Figures and the Mitotic Index in Cervical Intraepithelial Neoplasia about?

We surveyed cervical intraepithelial neoplasia (CIN) to quantify the proliferation rate and the presence of normal and atypical mitotic figures. In the cervical tissue specimens of 127 women with CIN, the area with the highest cell proliferation was identified and, at that site, the proliferation rate was assessed by calculating the mitotic index (MI). Lesions with an MI <2 were not considered further. In the area with the highest proliferation rate, 228 mitoses were classified into one of the following groups: normal mitotic figures (NMFs), lag-type mitoses (LTMs) comprising three group metaphases (3GMs), two group metaphases (2GMs) and other lag-type mitoses (OLTMs), multipolar mitoses (MPMs) comprising tripolar mitoses (3PMs) and quadripolar mitoses (4PMs), and other atypical mitotic figures (OAMFs). The median value of the MI increased significantly from 3 in CIN I through 4 in CIN II to 9 in CIN III (P<0.001). The occurrence of the different LTMs was mutually correlated. The frequency of LTMs increased significantly with increasing CIN grade (P<0.001), whereas the frequency of NMFs decreased significantly with increasing CIN grade (P<0.001). The frequency of OAMEs was not rela

Who reads Atypical Mitotic Figures and the Mitotic Index in Cervical Intraepithelial Neoplasia?

Author

A. M. Van Leeuwen; P. M. Burger; W. J. L. M. Pieters; H. Hollema

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1995

Language

EN

Field

Medicine (Health Sciences)