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The clinical implication and prognostic predictors of tigecycline treatment for pneumonia involving multidrug-resistant Acinetobacter baumannii by Jung-Jr Ye; Huang-Shen Lin; An-Jing Kuo; Hsieh-Shong Leu; Ping-Cherng Chiang; Ching-Tai Huang; Ming-Hsun Lee is a Medicine article available to read on EtoBox.
What is The clinical implication and prognostic predictors of tigecycline treatment for pneumonia involving multidrug-resistant Acinetobacter baumannii about?
## Objectives: To investigate the clinical implication and prognostic predictors of tigecycline treatment for pneumonia involving multidrug-resistant acinetobacter baumannii (mdrab). ## Methods: A retrospective observational study over a 32-month period for adult patients receiving tigecycline treatment at least 7 days for pneumonia involving mdrab. ## Results: We reviewed 112 patients with 116 episodes of tigecycline-treated pneumonia involving mdrab. the mean age was 70.8 years. the mean acute physiology and chronic health evaluation (apache) ii score was 21.7. seventy episodes (60.3%) had clinical resolution. the episodes with monomicrobial mdrab pneumonia had a significantly lower clinical resolution rate than polymicrobial pneumonia (14/31, 45.2% vs. 56/85, 65.9%; p = 0.044). the independent predictors for failure of clinical resolution were female gender, malignancy, bilateral pneumonia, monomicrobial pneumonia, and higher aphche ii scores. forty-two episodes (36.2%) had the 30-day mortality, and the only independent predictor was deterioration of pneumonia on chest radiographs. ## Conclusions: A high disease severity, bilateral pneumonia, and monomicrobial mdrab pneumonia pr
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- Author
- Jung-Jr Ye; Huang-Shen Lin; An-Jing Kuo; Hsieh-Shong Leu; Ping-Cherng Chiang; Ching-Tai Huang; Ming-Hsun Lee
- Publisher
- Elsevier BV
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)