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Effects of adrenalectomy and DOCA on the DPN- and TPN-diaphorase activities in the early stages of liver carcinogenesis induced by 3′-methyl-4-dimethylaminoazobenzene by D. C. Hadjiolov is a Medicine article available to read on EtoBox.

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Comparative cytochemical studies on the activity of DPN-diaphorase, TPNdiaphorase and some coenzyme-dependent dehydrogenases revealed marked differences in the degree of liver parenchymal damage of intact and adrenalectomized rats fed The quantity of formazan deposits, that is, the activity of DPN-and TPN-diaphorase in intact animals, sharply decreased afrer rats were fed a carcinogenic diet for 60 days. Coarse formazan granules, in nest-like formations, occurred in the cells, Enzyme activity did not decrease in adrenalecfomized rats treated with I0 mg DOCA weekly. Adrenalectomy and DOCA treatment were nevertheless incapable of providing absolute protection of the liver parenchyma. Coarse formazan granules were detected in the central areas of the liver lobules. These marked quantitative differences in the degree of liver damage in intact and adrenalectomized rats may indirectly affect the occurrence of "oval cell prolqeration '' and thus the further progression of malignancy.

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Author

D. C. Hadjiolov

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1966

Language

EN

Field

Medicine (Health Sciences)