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Towards Systems Immunology of Critical Illness at Scale: from Single Cell ‘Omics to Digital Twins by Yoram Vodovotz is a Immunology and Microbiology article available to read on EtoBox.

What is Towards Systems Immunology of Critical Illness at Scale: from Single Cell ‘Omics to Digital Twins about?

Single-cell ‘omics methodology has yielded unprecedented insights based largely on data-centric informatics for reducing, and thus interpreting, massive datasets. In parallel, parsimonious mathematical modeling based on abstractions of pathobiology has also yielded major insights into inflammation and immunity, with these models being extended to describe multi-organ disease pathophysiology as the basis of ‘digital twins’ and in silico clinical trials. The integration of these distinct methods at scale can drive both basic and translational advances, especially in the context of critical illness, including diseases such as COVID-19. Here, I explore achievements and argue the challenges that are inherent to the integration of data-driven and mechanistic modeling approaches, highlighting the potential of modeling-based strategies for rational immune system reprogramming.

Who reads Towards Systems Immunology of Critical Illness at Scale: from Single Cell ‘Omics to Digital Twins?

Author

Yoram Vodovotz

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)