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Can I read PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy on EtoBox?
PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy by Lu Wang; Bo Fu; Da-Yong Hou; Yu-Lin Lv; Guang Yang; Cong Li; Jia-Chen Shen; Bin Kong; Li-Bo Zheng; Yu Qiu; Hong-Lei Wang; Chen Liu; Jian-Ji Zhang; Shi-Yu Bai; Li-Li Li; Hao Wang; Wan-Hai Xu is a Engineering article available to read on EtoBox.
What is PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy about?
Stronger intrinsic Warburg effect and resistance to chemotherapy are the responses to high mortality of renal cell carcinoma (RCC). Pyruvate kinase M2 (PKM2) plays an important role in this process. Promoting PKM2 conversion from dimer to tetramer is a critical strategy to inhibit Warburg effect and reverse chemotherapy resistance. Herein, a PKM2 allosteric converter (PAC) is constructed based on the “in vivo self-assembly” strategy, which is able to continuously stimulate PKM2 tetramerization. The PAC contains three motifs, a serine site that is protected by enzyme cleavable β-N-acetylglucosamine, a self-assembly peptide and a AIE motif. Once PAC nanoparticles reach tumor site via the EPR effect, the protective and hydrophilic β-N-acetylglucosamine will be removed by over-expressed O-GlcNAcase (OGA), causing self-assembled peptides to transform into nanofibers with large serine (PKM2 tetramer activator) exposure and long-term retention, which promotes PKM2 tetramerization continuously. Our results show that PAC-induced PKM2 tetramerization inhibits aberrant metabolism mediated by Warburg effect in cytoplasm. In this way, tumor proliferation and metastasis behavior could be effecti
Who reads PKM2 allosteric converter: A self-assembly peptide for suppressing renal cell carcinoma and sensitizing chemotherapy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Lu Wang; Bo Fu; Da-Yong Hou; Yu-Lin Lv; Guang Yang; Cong Li; Jia-Chen Shen; Bin Kong; Li-Bo Zheng; Yu Qiu; Hong-Lei Wang; Chen Liu; Jian-Ji Zhang; Shi-Yu Bai; Li-Li Li; Hao Wang; Wan-Hai Xu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)