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Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation by Caroline Dudreuilh; Sumoyee Basu; Cristiano Scottà; Anthony Dorling; Giovanna Lombardi is a Immunology and Microbiology article available to read on EtoBox.

What is Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation about?

Regulatory T cells (Tregs) constitute a small proportion of circulating CD4^+^ T cells that function to maintain homeostasis and prevent autoimmunity. In light of their powerful immunosuppressive and tolerance-promoting properties, Tregs have become an interesting potential candidate for therapeutic use in conditions such as solid organ transplant or to treat autoimmune and inflammatory conditions. Clinical studies have demonstrated the safety of polyclonally expanded Tregs in graft-versus-host disease, type 1 diabetes, and more recently in renal and liver transplantation. However, Tregs are heterogenous. Recent insights indicate that only a small proportion of Tregs, called T follicular regulatory cells (Tfr) regulate interactions between B cells and T follicular helper (Tfh) cells within the germinal center. Tfr have been mainly described in mouse models due to the challenges of sampling secondary lymphoid organs in humans. However, emerging human studies, characterize Tfr as being CD4^+^CD25^+^FOXP3^+^CXCR5^+^ cells with different levels of PD-1 and ICOS expression depending on their localization, in the blood or the germinal center. The exact role they play in transplantation r

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Author

Caroline Dudreuilh; Sumoyee Basu; Cristiano Scottà; Anthony Dorling; Giovanna Lombardi

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)