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Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC) by John Yu; Seong‐Sil Chang; Sanjeev Suratwala; Woo‐Sik Chung; Peter Abdelmessieh; Hahn‐Jun Lee; Jay Yang; Francis Young‐In Lee is a Medicine article available to read on EtoBox.
What is Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC) about?
## Abstract Unicameral bone cyst (UBC) is a benign cystic lesion in children which is prone to fracture. Various treatments are available, but recurrence after different types of percutaneous injection therapy can cause bone destruction and pathologic fracture. The potential therapeutic effects of anti‐resorptive agents, such as bisphosphonates, have not been investigated for UBC. The objective of this study was to characterize the cells from the fibro‐cellular membrane of unicameral bone cyst (UBC cells) and to determine whether zoledronate, a nitrogen‐containing bisphosphonate, could induce apoptosis in UBC cells. Flow cytometry and immunoblotting were performed in order to determine whether zoledronate induced apoptosis. Cells derived from normal human trabecular bones were used as controls against UBC cells to compare the effect of zoledronate in inducing apoptosis. Immunohisto/cytochemistry (IHC/ICC) and mini‐array analyses were performed on tissues and cultured cells. Isolated peripheral blood mononuclear cells were incubated with conditioned media from the UBC cells to determine whether they are capable of inducing osteoclastogenesis. UBC membrane is composed of cells staini
Who reads Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- John Yu; Seong‐Sil Chang; Sanjeev Suratwala; Woo‐Sik Chung; Peter Abdelmessieh; Hahn‐Jun Lee; Jay Yang; Francis Young‐In Lee
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)