About this Medicine article
Clinical Impact of Adjuvant Radiation Therapy Delay After Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer by Saulo Brito Silva; Allan Andresson Lima Pereira; Gustavo Nader Marta; Kennya Medeiros Lopes de Barros Lima; Thiago Brasileiro de Freitas; Adriana Reis Brandão Matutino; Manoel Carlos Leonardi de Azevedo Souza; Renata Gondim Meira Velame de Azevedo; Pedro Antonio Hermida de Viveiros; Julianne Maria da Silva Lima; José Roberto Filassi; Heloísa de Andrade Carvalho; José Roberto Morales Piato; Max S. Mano is a Medicine article available to read on EtoBox.
## Background: And purpose: post-operative radiation therapy (port) is usually indicated for patients with breast cancer (bc) after neoadjuvant chemotherapy (nac) and surgery. however, the optimal timing to initiation of port is currently unknown. ## Material and methods: We retrospectively evaluated data from patients with bc who received port after nac and surgery at our institution from 2008 to 2014. patients were categorized into three groups according to the time between surgery and port: 16 weeks. ## Results: A total of 581 patients were included; 74% had clinical stage iii. forty-three patients started port within 8 weeks, 354 between 8 and 16 weeks and 184 beyond 16 weeks from surgery. with a median follow-up of 32 months, initiation of port up to 8 weeks after surgery was associated with better disease-free survival (dfs) (<8 weeks versus 8-16 weeks: hr 0.33; 95% ci 0.13-0.81; p = 0.02; 16 weeks: hr 0.38; 95% ci 0.15-0.96; p = 0.04) and better overall survival (os) (<8 weeks versus 8-16 weeks: hr 0.22; 95% ci 0.05-0.90; p = 0.036; 16 weeks: hr 0.28; 95% ci 0.07-1.15; p = 0.08). ## Conclusion: Port started up to 8 weeks after surgery was associated with better dfs and os
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- Author
- Saulo Brito Silva; Allan Andresson Lima Pereira; Gustavo Nader Marta; Kennya Medeiros Lopes de Barros Lima; Thiago Brasileiro de Freitas; Adriana Reis Brandão Matutino; Manoel Carlos Leonardi de Azevedo Souza; Renata Gondim Meira Velame de Azevedo; Pedro Antonio Hermida de Viveiros; Julianne Maria da Silva Lima; José Roberto Filassi; Heloísa de Andrade Carvalho; José Roberto Morales Piato; Max S. Mano
- Publisher
- Elsevier BV
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)