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Changes in exploratory activity following stimulation of hippocampal 5-HT1A and 5-HT1B receptors in the rat by Marie-Christine Buhot; Said Naili is a Neuroscience article available to read on EtoBox.

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The object exploration task allows the measure of changes in locomotor and exploratory activities, habituation, and reaction to a spatial change and to novelty. The effects of intrahippocampal (dorsal CAI field) microinjections of serotonin 1 receptor (5-HT1) agonists on these behavioral components were evaluated in the rat. 8-Hydroxy-2-(din-propy1amino)-tetralin (8-OH-DPAT, 5 pg/pl) was used as a 5-HTIA agonist, 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (CP 93,129, 16 pg/pI) as a 5-HT1 B agonist, and scopolamine (1 0 pg/pI) as a muscarinic cholinergic antagonist. Scopolamine induced a long-lasting increase in locomotor activity and a lack of reaction to spatial change; both these results are in agreement with the known crucial influence of the septo-hippocampal cholinergic system in hippocampal functioning. Stimulation of 5-HT1A and 5-HT1 B receptors induced a decrease in object exploration and habituation without affecting the retrieval of spatial information. But stimulation of hippocampal 5-HT1 B receptors induced a selective change in the animal's emotional state, i.e., an initial decrease in locomotor activity and a neophobic reaction in response to a new obje

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Author

Marie-Christine Buhot; Said Naili

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

1995

Language

EN

Field

Neuroscience (Life Sciences)