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Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants by Ghosh, Anita K.; Rao, Vidhya R.; Wisniewski, Victoria J.; Zigrossi, Alexandra D.; Floss, Jamie; Koulen, Peter; Stubbs, Evan B; Kaja, Simon is a Medicine article available to read on EtoBox.
What is Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants about?
Optic nerve head astrocytes are the specialized glia cells that provide structural and trophic support to the optic nerve head. In response to cellular injury, optic nerve head astrocytes undergo reactive astrocytosis, the process of cellular activation associated with cytoskeletal remodeling, increases in the rate of proliferation and motility, and the generation of Reactive Oxygen Species. Antioxidant intervention has previously been proposed as a therapeutic approach for glaucomatous optic neuropathy, however, little is known regarding the response of optic nerve head astrocytes to antioxidants under physiological versus pathological conditions. The goal of this study was to determine the effects of three different antioxidants, manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin (Mn-TM-2-PyP), resveratrol and xanthohumol in primary optic nerve head astrocytes. Effects on the expression of the master regulator nuclear factor erythroid 2-related factor 2 (Nrf2), the antioxidant enzyme, manganese-dependent superoxide dismutase 2 (SOD2), and the pro-oxidant enzyme, nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), were determined by quantitative immunoblotting. Furt
Who reads Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ghosh, Anita K.; Rao, Vidhya R.; Wisniewski, Victoria J.; Zigrossi, Alexandra D.; Floss, Jamie; Koulen, Peter; Stubbs, Evan B; Kaja, Simon
- Publisher
- MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI AG, 2012- (ISSN 2076-3921)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)