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This document describes a study that discovered and evaluated small molecule compounds that block the nNav1.5 sodium channel, which is overexpressed in aggressive breast cancer cells and promotes cancer cell invasion and metastasis. The researchers developed a 3D-QSAR model to guide the design of low micromolar nNav1.5 blockers. They synthesized five small molecule compounds and found that one compound blocked sodium currents in breast cancer cells by 34.9% at 1 μM and inhibited cancer cell invasion by 30.3

Author

Abby Vásquez

Language

EN