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Structure, Depolymerization, and Cytocompatibility Evaluation of Glycol Chitosan by Darryl K. Knight; Stephen N. Shapka; Brian G. Amsden is a Engineering article available to read on EtoBox.

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## Abstract Glycol chitosan, a water soluble chitosan derivative being investigated as a new biomaterial, was fractionated via two different methods. Initial characterization of the glycol chitosan with ^1^H NMR spectroscopy illustrated the presence of both secondary and tertiary amine groups, contradictory to its widely accepted structure. Fractionation of glycol chitosan with nitrous acid resulted in a significant reduction in the number average molecular weight, specifically, from 170 to ∼7 kDa for a pH 3 and below. However, the reaction altered its chemical structure, as the secondary amine groups were converted to __N__‐nitrosamines, which are potentially carcinogenic. An increase in the pH of the reaction limited this formation, but not entirely. Free radical degradation initiated with potassium persulfate was not as effective at reducing the molecular weight as the nitrous acid approach, yielding molecular weights around 12 kDa under the same molar ratio of degrading species, but did retain the structural integrity of the glycol chitosan. Additionally, control of the molecular weight appears feasible with potassium persulfate. When assessed __in vitro__ for cytocompatibility

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Author

Darryl K. Knight; Stephen N. Shapka; Brian G. Amsden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2007

Language

EN

Field

Engineering (Physical Sciences)