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Haptoglobin Genotype Is a Determinant of Survival and Cardiac Remodeling After Myocardial Infarction in Diabetic Mice by Roy Asaf; Shany Blum; Ariel Roguin; Shiri Kalet-Litman; Jad Kheir; Avi Frisch; Rachel Miller-Lotan; Andrew P Levy is a Medicine article available to read on EtoBox.
What is Haptoglobin Genotype Is a Determinant of Survival and Cardiac Remodeling After Myocardial Infarction in Diabetic Mice about?
## Background: We have recently demonstrated in man that a functional allelic polymorphism in the haptoglobin (hp) gene plays a major role in determining survival and congestive heart failure after myocardial infarction (mi). we sought to recapitulate the effect of hp type on outcomes and cardiac remodeling after mi in transgenic mice. ## Methods: The hp 2 allele exists only in man. wild type c57bl/6 mice carry the hp 1 allele with high homology to the human hp 1 allele. we genetically engineered a murine hp 2 allele and targeted its insertion by homologous recombination to the murine hp locus to create hp 2 mice. diabetes mellitus (dm) was induced with streptozotocin. mi was produced by occlusion of the left anterior descending artery in dm c57bl/6 mice carrying the hp 1 or hp 2 allele. mi size was determined with ttc staining. left ventricular (lv) function and dimensions were assessed by 2-dimensional echocardiography. ## Results: In the absence of dm, hp 1-1 and hp 2-2 mice had similar lv dimensions and lv function. mi size was similar in dm hp 1-1 and 2-2 mice 24 hours after mi (50.2 +/- 2.1%and 46.9 +/- 5.5%, respectively, p = 0.6). however, dm hp 1-1 mice had a significantly
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- Author
- Roy Asaf; Shany Blum; Ariel Roguin; Shiri Kalet-Litman; Jad Kheir; Avi Frisch; Rachel Miller-Lotan; Andrew P Levy
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)