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Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats by Alexander Panossian; Areg Hovhannisyan; Hasmik Abrahamyan; Emil Gabrielyan; Georg Wikman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Significant pharmacokinetic/pharmacodynamic interactions between various herbal products and drugs being substrates of cytochrome P450 have recently been reported. The aim of this study was to determine whether __Rhodiola rosea__ SHR‐5 extract interacts with warfarin and theophylline when administered concomitantly. Thus, concomitant treatment of rats with theophylline and SHR‐5 did not give rise to significant effects on the pharmacokinetics of theophylline. Simultaneous administration of SHR‐5 and warfarin did not alter significantly the pharmacokinetics or the anticoagulant activity of warfarin. It is concluded that SHR‐5 might be of value in the treatment of patients with mild or moderate depression, and that its interaction with co‐administered drugs is likely to be negligible. Copyright © 2008 John Wiley & Sons, Ltd.

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Author

Alexander Panossian; Areg Hovhannisyan; Hasmik Abrahamyan; Emil Gabrielyan; Georg Wikman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)