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What is JP 1302 about?

The document discusses a new compound called JP-1302 that is a highly selective antagonist of the α2C-adrenoceptor subtype. Studies in mice and rats found that JP-1302 showed antidepressant-like effects in behavioral tests, but did not impair prepulse inhibition, and could reverse phencyclidine-induced prepulse inhibition impairments. This compound provides a new tool to help understand the functional roles of the α2C-adrenoceptor in the brain.

Author

Attila Tamas

Language

EN