Can I read Sensory neurons shape local macrophage identityvia TGF-β signaling on EtoBox?

Sensory neurons shape local macrophage identityvia TGF-β signaling by Julia Kolter & Clarissa-Laura Döring & Samah Sarout & Sebastian Baasch & Lloyd Steele & Reem Alsumati & Gabriel V. Lucena Silva & Conceição E. Aníbal Silva & Isadora Marques Paiva & Zohreh Mansoori Moghadam & Vitka Gres & Florens Lohrmann & Philipp... is a nonfiction available to read on EtoBox.

What is Sensory neurons shape local macrophage identityvia TGF-β signaling about?

Immunity, Corrected proof. doi:10.1016/j.immuni.2025.08.004SUMMARY: Resident macrophages play integral roles in maintaining tissue homeostasis and function. In the skin, prenatally seeded, specialized macrophages patrol sensory nerves and contribute to their regeneration after injury.However, mechanisms underlying the long-lasting postnatal commitment of these nerve-associated macrophages remain largely elusive. Here, we found that traumatic injury induced recruitment of myeloid progenitor cells to the sprouting axons of sensory nerves, where they gradually acquired a nerve-associated macrophage-like profile. This identity change was driven and maintained by the immediate microenvironment,particularly by transforming growth factor-β (TGF-β), which was locally activated by the physical interactionwith nerves and integrin-mediated cleavage, and by the neuropeptide calcitonin gene-related peptide(CGRP). Moreover, TGF-β-mediated macrophage specification was essential for proper nerve regenerationfollowing injury. Overall, we identify TGF-β as a conserved, spatially regulated mediator governing localimprinting and long-term specialization of macrophages within the subtissular neurona

Who reads Sensory neurons shape local macrophage identityvia TGF-β signaling?

Author

Julia Kolter & Clarissa-Laura Döring & Samah Sarout & Sebastian Baasch & Lloyd Steele & Reem Alsumati & Gabriel V. Lucena Silva & Conceição E. Aníbal Silva & Isadora Marques Paiva & Zohreh Mansoori Moghadam & Vitka Gres & Florens Lohrmann & Philipp...

Published

2025

Language

EN

Category

nonfiction

Subjects

Medical, Neuroscience, Medicine