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A Maternal Low Protein Diet Has Pronounced Effects on Mitochondrial Gene Expression in Offspring Liver and Skeletal Muscle; Protective Effect of Taurine by Ole Hartvig Mortensen; Hanne Lodberg Olsen; Lis Frandsen; Peter Eigil Nielsen; Cilius Finn Nielsen; Niels Grunnet; Bjørn Quistorff is a Medicine article available to read on EtoBox.
What is A Maternal Low Protein Diet Has Pronounced Effects on Mitochondrial Gene Expression in Offspring Liver and Skeletal Muscle; Protective Effect of Taurine about?
## Background: Low birth weight is associated with an increased risk of developing impaired glucose tolerance, and eventually type 2 diabetes in adult life. gestational protein restriction in rodents gives rise to a low birth weight phenotype in the offspring. ## Results: We examined gene expression changes in liver and skeletal muscle of mice subjected to gestational protein restriction (lp) or not (np), with or without taurine supplementation in the drinking water. lp offspring had a 40% lower birth weight than np offspring, with taurine preventing half the decrease. microarray gene expression analysis of newborn mice revealed significant changes in 2012 genes in liver and 967 genes in skeletal muscle of lp offspring. taurine prevented 30% and 46% of these expression changes, respectively. mitochondrial genes, especially those involved with oxidative phosphorylation, were more abundantly changed than other genes. the mitochondrial genes were mainly upregulated in liver, but downregulated in skeletal muscle, despite no change in citrate synthase activity in either tissue. taurine preferentially rescued genes concerned with fatty acid metabolism in liver and with oxidative phosphor
Who reads A Maternal Low Protein Diet Has Pronounced Effects on Mitochondrial Gene Expression in Offspring Liver and Skeletal Muscle; Protective Effect of Taurine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ole Hartvig Mortensen; Hanne Lodberg Olsen; Lis Frandsen; Peter Eigil Nielsen; Cilius Finn Nielsen; Niels Grunnet; Bjørn Quistorff
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); BioMed Central Ltd.; [Basel Switzerland]: Karger; London: 2009-; Springer Science and Business Media LLC; S. Karger AG; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1021-7770)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Life Sciences)