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Therapeutic Angiogenesis: From Basic Science to The Clinic (Ernst Schering Research Foundation Workshop) by J.A. Dormandy, W.P. Dole, G.M. Rubanyi, editors is a book available to read on EtoBox.

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Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g., heart, brain, skeletal muscle) during criti­ cal ischemia has prompted novel therapeutic strategies to stimulate/fa­ cilitate angiogenesis and collateral formation in ischemic conditions ('therapeutic angiogenesis'). Therapeutic angiogenesis describes a strategy of inducing new col­ lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en­ hance tissue oxygen exchange. Naturally occurring growth factors (e. g., FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap­ plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis­ sues. Therapeutic angiogenesis therefore represents a new medical pr

Author

J.A. Dormandy, W.P. Dole, G.M. Rubanyi, editors

Publisher

Springer Spektrum. in Springer-Verlag GmbH

Published

2013

Language

EN

ISBN

9783540656937

Subjects

Medical, Nursing, Medicine