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Propionibacterium acnes contributes to low back pain via upregulation of NGF in TLR2-NF-κB/JNK or ROS pathway 1 1. Materials and methods 2 1.1. Preparation of P. acnes 2 1.2. Co-cultures of nucleus pulposus cells (NPCs) with P. acnes 2 1.3. Infected IVD model in rats 2 1.4. Behavioral quantification of nociception 2 1.5. Transfection of siRNA-TLR2 and inhibition of the signal pathway 2 1.6. Western blot 2 1.7. Real-time quantitative PCR 2 1.8. Enzyme-linked immunosorbent assay (ELISA) 3 1.9. Immunofluorescence 3 1.10. Immunohistochemistry (IHC) 3 1.11. Cell viability assay 3 1.12. Statistical analysis 4 2. .Results 4 2.1. P. acnes stimulated NPCs to produce excessive NGF in a time-dependent manner 4 2.2. Inoculation of P. acnes into caudal IVDs caused prolonged NGF over-expression 4 2.3. P. acnes caused LBP via NGF 5 2.4. P. acnes induced NGF expression via the TLR-2 receptor and JNK/NF-κB signal pathway, but not ERK and p38 MAPK pathways in NPCs 7 2.5. ROS induced by P. acnes also contributed to NGF production and caused LBP 7 3. Discussion 7 4. Conclusion 9 Data availability 9 Declaration of competing interest 9 Acknowledgments 9 Appendix A. Supplementary data 9 References 9

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nonfiction