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Assessing and Predicting Physical Stability of Emulsion-Based Topical Semisolid Products: A Review by Abu Zayed Md Badruddoza; Thean Yeoh; Jaymin C Shah; Taylor Walsh is a Chemistry article available to read on EtoBox.

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The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity. These complex microstructures are thermodynamically unstable, and the physical stability of such preparations is governed by formulation parameters such as phase volume ratio, type of emulsifiers and their concentration, HLB value of the emulsifier, as well as by process parameters such as homogenizer speed, time, temperature etc. Therefore, a detailed understanding of the microstructure in the DP and critical factors that influence the stability of emulsions is essential to ensure the quality and shelf-life of emulsion-based topical semisolid products. This review aims to provide an overview of the main strategies used to stabilize pharmaceutical emulsions contained in semisolid products and various characterization techniques and tools that have been utilized so far to evaluate their long-term stability. Accelerated physical stability assessment using dispersion analyzer tools such as an analytical centrifuge to predict the product shelf-life has

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Author

Abu Zayed Md Badruddoza; Thean Yeoh; Jaymin C Shah; Taylor Walsh

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)