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Safety and efficacy of mycophenolate in COVID-19: a nonrandomised prospective study in western India by Atul Sajgure; Ajit Kulkarni; Atul Joshi; Vasanti Sajgure; Vaishali Pathak; Rashida Melinkeri; Shilpa Pathak; Sumit Agrawal; Manoj Naik; Milind Rajurkar; Ameya Sajgure; Girish Date is a Medicine article available to read on EtoBox.
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## Summary ## Background Antivirals and immunosuppressive agents are used with variable success in the treatment of COVID-19. Mycophenolate, an inhibitor of enzyme inosine monophosphate dehydrogenase, is an immunosuppressant used to prevent allograft rejection and other autoimmune diseases. Few laboratory studies have also reported antiviral properties of mycophenolate. The current study tried to assess the safety and efficacy of mycophenolate in patients hospitalised with COVID-19. ## Methods This was a prospective non-randomised open label study with the objective to assess the effect of addition of mycophenolate to the standard of care on mortality due to COVID-19 and duration of hospital stay. The target study population was comprised of patients requiring inpatient treatment for COVID-19 during the period from Jan 15–April 15, 2021. The study was registered with Clinical Trial Registry of India (CTRI/2021/01/030477, registered on date—14/01/2021). Adult patients (n = 106) requiring hospitalisation for COVID-19 received mycophenolate, 360 mg, one tablet daily for one month. Mycophenolate was initiated within 48 h of the diagnosis of SARS-CoV-2 infection by RT‒PCR. While patient
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- Author
- Atul Sajgure; Ajit Kulkarni; Atul Joshi; Vasanti Sajgure; Vaishali Pathak; Rashida Melinkeri; Shilpa Pathak; Sumit Agrawal; Manoj Naik; Milind Rajurkar; Ameya Sajgure; Girish Date
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)