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Genome‐wide scan of brothers: Replication and fine mapping of prostate cancer susceptibility and aggressiveness loci by John S. Witte; Brian K. Suarez; Bonnie Thiel; Jennifer Lin; Adong Yu; Tarit K. Banerjee; James K. Burmester; Graham Casey; William J. Catalona is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND Substantial evidence suggests that genetic factors play an important role in both the risk of prostate cancer and its biologic aggressiveness. Here we investigate prostate cancer susceptibility and aggressiveness with genome‐wide linkage analyses of affected brothers. ## METHODS We first undertook a new genome‐wide linkage study of 259 brothers with prostate cancer. Our analyses tested whether the proportion of marker alleles shared by brothers was correlated with disease status or Gleason score. To further clarify 11 linkage regions observed here or previously, we genotyped and analyzed an additional 101 finely spaced markers in the 259 men, and in 594 previously studied brothers, allowing for a pooled genome‐wide analysis of 853 affected brothers. ## RESULTS In the new study, we detected linkage to prostate cancer on chromosome 16q23 (__P__ = 0.009), replicating previous results, and to chromosome 11q24 (__P__ = 0.001). In the pooled analysis, the 16q23 linkage was strengthened (__P__ = 0.0005), as was our previous linkage to chromosome 16p (__P__ = 0.0001), and we detected linkage to chromosome 2q32 (__P__ = 0.009). When evaluating Gleason score, our ne

Who reads Genome‐wide scan of brothers: Replication and fine mapping of prostate cancer susceptibility and aggressiveness loci?

Author

John S. Witte; Brian K. Suarez; Bonnie Thiel; Jennifer Lin; Adong Yu; Tarit K. Banerjee; James K. Burmester; Graham Casey; William J. Catalona

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2003

Language

EN

Field

Medicine (Health Sciences)