Can I read Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy on EtoBox?

Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy by Turrini, Mauro (author);Gardellini, Angelo (author);Beretta, Livia (author);Buzzi, Lucia (author);Ferrario, Stefano (author);Vasile, Sabrina (author);Clerici, Raffaella (author);Colzani, Andrea (author);Liparulo, Luigi (author);Scognamiglio, Giovanni (author);Imperiali, Gianni (author);Corrado, Giovanni (author);Strada, Antonello (author);Galletti, Marco (author);Castiglione, Nunzio (author);Zanon, Claudio (author) is a Medicine article available to read on EtoBox.

What is Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy about?

The aim of this study is to explore risk factors for in-hospital mortality and describe the effectiveness of different treatment strategies of 205 laboratory-confirmed cases infected with SARS-CoV-2 during the Lombardy outbreak. All patients received the best supportive care and specific interventions that included the main drugs being tested for repurposing to treat COVID-19, such as hydroxychloroquine, anticoagulation and antiviral drugs, steroids, and interleukin-6 pathway inhibitors. Clinical, laboratory, and treatment characteristics were analyzed with univariate and multivariate logistic regression methods to explore their impact on in-hospital mortality. Univariate analyses showed prognostic significance for age greater than 70 years, the presence of two or more relevant comorbidities, a P/F ratio less than 200 at presentation, elevated LDH (lactate dehydrogenase) and CRP (C-reactive protein) values, intermediate- or therapeutic-dose anticoagulation, hydroxychloroquine, early antiviral therapy with lopinavir/ritonavir, short courses of steroids, and tocilizumab therapy. Multivariable regression confirmed increasing odds of in-hospital death associated with age older than 70

Who reads Clinical Course and Risk Factors for In-Hospital Mortality of 205 Patients with SARS-CoV-2 Pneumonia in Como, Lombardy Region, Italy?

Author

Turrini, Mauro (author);Gardellini, Angelo (author);Beretta, Livia (author);Buzzi, Lucia (author);Ferrario, Stefano (author);Vasile, Sabrina (author);Clerici, Raffaella (author);Colzani, Andrea (author);Liparulo, Luigi (author);Scognamiglio, Giovanni (author);Imperiali, Gianni (author);Corrado, Giovanni (author);Strada, Antonello (author);Galletti, Marco (author);Castiglione, Nunzio (author);Zanon, Claudio (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)