About this Engineering article
Tailoring Cu2+-loaded electrospun membranes with antibacterial ability for guided bone regeneration by Jairo M. Cordeiro; Valentim A.R. Barão; Erica D. de Avila; Johanna F.A. Husch; Fang Yang; Jeroen J.J.P. van den Beucken is a Engineering article available to read on EtoBox.
Copper (Cu)-loaded electrospun membranes were tailored for guided bone regeneration (GBR), targeting the stimulation of innate cells active in bone growth and the prevention of bacterial infections. Functional GBR membranes were produced via an electrospinning set-up using a silk-based solution associated with polyethylene oxide (Silk/PEO -control). Experimental groups were loaded with copper oxide using varying weight percentages (0.05 % to 1 % of CuO). The morphological, structural, chemical, and mechanical properties of membranes were evaluated. Direct and indirect in vitro cytocompatibility experiments were performed with primary human bone mesenchymal stem cells and primary human umbilical vein endothelial cells. The antibacterial potential of membranes was tested with Staphylococcus aureus and Fusobacterium nucleatum biofilm. CuO was successfully incorporated into membranes as clusters without compromising their mechanical properties for clinical applicability. Increased Cu concentrations generated membranes with thinner nanofibers, greater pore areas, and stronger antimicrobial effect (p < 0.01). Cu 2+ ion was released from the nanofiber membranes during 1 week, showing high
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jairo M. Cordeiro; Valentim A.R. Barão; Erica D. de Avila; Johanna F.A. Husch; Fang Yang; Jeroen J.J.P. van den Beucken
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)