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Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: Pertussis toxin treatment inhibits activation of phospholipid signaling, calcium oscillation, and mitogen-activated protein kinase by T Adachi; S Nakashima; S Saji; T Nakamura; Y Nozawa is a Medicine article available to read on EtoBox.

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cells. [1][2][3][4] The HGF receptor is the c-met proto-oncogene prod-Treatment of primary cultured rat hepatocytes with hepatouct that has tyrosine kinase activity. Several signaling events cyte growth factor (HGF) gives rise to inositol phosphate forhave been reported to occur after HGF-receptor activation. 5,6 mation, cytosolic calcium oscillation, activation of mitogen-acti-HGF causes the tyrosine phosphorylation of phosphatidylvated protein (MAP) kinase and phospholipase D (PLD), and inositol-specific phospholipase Cg 1 (PI-PLCg 1 ), 7 leading to arachidonic acid release, leading to DNA synthesis. Pretreatinositol trisphosphate (IP 3 ) formation and an increase in ment of cultured hepatocytes with pertussis toxin (PT), which intracellular Ca 2/ concentration ([Ca 2/ ] i ). 8,9 In contrast to is known to adenosine diphosphate-ribosylate Gi and Go guathe rapid and transient change in IP 3 , 1,2-diacylglycerol (1,2nine nucleotide-binding proteins and to inhibit their functions, DG) formation was biphasic, and the second sustained phase partially inhibited HGF-induced [ 3 H]thymidine incorporation was mainly due to phosphatidylcholine hydrolysis. 10 Furin a concentration-dependent

Who reads Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes: Pertussis toxin treatment inhibits activation of phospholipid signaling, calcium oscillation, and mitogen-activated protein kinase?

Author

T Adachi; S Nakashima; S Saji; T Nakamura; Y Nozawa

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

1997

Language

EN

Field

Medicine (Health Sciences)