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Vasodilator action of prostaglandin E~1~ on microcirculation of rat cremaster muscle by Long-En Chen; Anthony V. Seaber Mr.; James R. Urbaniak is a Medicine article available to read on EtoBox.

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## Abstract Vascular spasm is often present after microsurgical procedures, and its presence or absence can greatly influence the success rate of such operations. Prostaglandin E~1~ (PGE1) is known to be a potent vasodilator and antiaggregator of small blood vessels. Using intravital videomicroscopy in the rat cremaster model, this study visually and quantitatively monitored changes in vessel diameter to observe the effect of PGE1 on the microcirculation and compared its action with that of 1% lidocaine. The results suggest that PGE1 (10 μg/ml) can significantly relieve epinephrine‐induced vasoconstriction at the terminal arteriole, arteriole, and small artery level (vessel diameters 10–50 μm). The vasodilatory action of PGE1 is reflected by an increase in vessel diameter, and PGE1 may have a role in reversing vascular spasm after microsurgery, enhancing the survival rate of replanted extremities.

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Author

Long-En Chen; Anthony V. Seaber Mr.; James R. Urbaniak

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)

Published

1990

Language

EN

Field

Medicine (Health Sciences)