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Glucagon-like-1 Receptor Agonists and Sodium/glucose Cotransporter-2 Inhibitors Combination—are We Exploiting Their Full Potential in a Real Life Setting? by Maja Cigrovski Berkovic; Ines Bilic-Curcic; Tomislav Bozek; Davorka Herman Mahecic; Sanja Klobucar Majanovic; Silvija Canecki-Varzic; Jelena Andric; Srecko Marusic; Anna Mrzljak is a Medicine article available to read on EtoBox.

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## BACKGROUND The sodium/glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like-1 receptor agonists (GLP-1RA) are antidiabetic agents effective both in hemoglobin A1c (HbA1c) reduction (with a low risk of hypoglycemia) and cardiovascular event prevention. In patients with type 2 diabetes, the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems promising. ## AIM To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and follow-up. ## METHODS We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with (1) GLP-1RA on top of SGLT-2i, (2) SGLT-2i on top of GLP-1RA compared to (3) simultaneous addition of both agents. The primary study endpoint was the proportion of participants with HbA1c < 7.0% and/or 5% bodyweight reduction. Secondary outcomes included changes in fasting plasma glucose (FPG), prandial plasma glucose, low-density lipoprotein cholesterol, estimated glomerular filtration rate (eGFR), and cardiovascular (CV) incidents assessment ov

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Author

Maja Cigrovski Berkovic; Ines Bilic-Curcic; Tomislav Bozek; Davorka Herman Mahecic; Sanja Klobucar Majanovic; Silvija Canecki-Varzic; Jelena Andric; Srecko Marusic; Anna Mrzljak

Publisher

Baishideng Publishing Group Inc.

Published

2020

Language

EN

Field

Medicine (Health Sciences)