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Can I read A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer on EtoBox?
A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer by Han, Dong (author);Hooshangnejad, Hamed (author);Chen, Chin-Cheng (author);Ding, Kai (author) is a Medicine article available to read on EtoBox.
What is A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer about?
## Purpose We investigate two margin-based schemes for optimization target volumes (OTV), isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as one of the extreme sizes of margin, to study if the plan quality of 2 mm uniform expansion could be comparable to other plan schemes. ## Methods We developed two schemes for OTV, 1) a uniform expansion of 2 mm (OTV 2mm ), for setup uncertainty; 2) a water equivalent thickness based beam-specific expansion (OTV WET ) on beam direction and 2 mm expansion laterally. Six LAPC patients were planned with a prescribed dose of 33 Gy (RBE) in 5 fractions. Robustness optimization (RO) plans on GTV, with setup uncertainties of 2 mm and range uncertainties of 3.5%, are implemented as a benchmark. ## Results All three optimization schemes achieved decent target coverage with no significant difference. The OTV 2mm plans show superior organ at risk (OAR) sparing, especially for proximal duodenum. However, OTV 2mm plans demonstrate severe susceptibility to range and setup uncertainties with a passing rate o
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- Author
- Han, Dong (author);Hooshangnejad, Hamed (author);Chen, Chin-Cheng (author);Ding, Kai (author)
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)